top of page
このホームページは
.com
を使って作成されました。あなたも無料で作ってみませんか？今すぐはじめる
Test Tubes

Publications

  • 2024年

  • Hosen MB, Kawasumi R, Hirota K (2024) Dominant roles of BRCA1 in cellular tolerance to a chain-terminating nucleoside analog, alovudine. DNA Repair (Amst) 137: 103668

  • Rahman MR (2024) Proofreading exonuclease activity of replicative polymerase epsilon promotes cellular tolerance to arabinosides in CTF18-dependent and -independent manner. Genome Instability and Disease in press

  • Shibata T, Ikawa S, Iwasaki W, Sasanuma H, Masai H, Hirota K (2024) Homology recognition without double-stranded DNA-strand separation in D-loop formation by RecA. Nucleic Acids Res

  • Tsuruta Y, Senmatsu S, Oe H, Hoffman CS, Hirota K (2024) Metabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene. PLoS One 19: e0294191

  • 2023年

  • Ahmad T, Kawasumi R, Taniguchi T, Abe T, Terada K, Tsuda M, Shimizu N, Tsurimoto T, Takeda S, Hirota K (2023) The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands. Nucleic Acids Res 51: 12288-12302

  • Psakhye I, Kawasumi R, Abe T, Hirota K, Branzei D (2023) PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion. Nat Struct Mol Biol 30: 1286-1294

  • Washif M, Ahmad T, Hosen MB, Rahman MR, Taniguchi T, Okubo H, Hirota K, Kawasumi R (2023) CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε. DNA Repair (Amst) 127: 103503

  • Ikemoto, D., T. Taniguchi, K. Hirota, K. Nishikawa, K. Okubo, and T. Abe. 2023. Application of neural network-based image analysis to detect sister chromatid cohesion defects. Sci Rep 13:2133.

  • Ooka, M., S. Yang, L. Zhang, K. Kojima, R. Huang, K. Hirota, S. Takeda, and M. Xia. 2023. Lestaurtinib induces DNA damage that is related to estrogen receptor activation. Curr Res Toxicol 4:100102.

  • 2022年

  • Asada, R., and K. Hirota. 2022. Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription. Biomolecules 12.

  • Hirota, K. 2022. Regulation Mechanisms of Meiotic Recombination Revealed from the Analysis of a Fission Yeast Recombination Hotspot ade6-M26. Biomolecules 12.

  • Hirota, K., M. Ooka, N. Shimizu, K. Yamada, M. Tsuda, M. A. Ibrahim, S. Yamada, H. Sasanuma, M. Masutani, and S. Takeda. 2022. XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA. Genes Cells 27:331-344.

  • Li, J., A. Beiser, N. B. Dey, S. Takeda, L. K. Saha, K. Hirota, L. L. Parker, M. Carter, M. I. Arrieta, and R. W. Sobol. 2022. A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage. NAR Genom Bioinform 4:lqac065.

  • Nakano, T., T. Moriwaki, M. Tsuda, M. Miyakawa, Y. Hanaichi, H. Sasanuma, K. Hirota, M. Kawanishi, H. Ide, K. Tano, and T. Bessho. 2022. SPRTN and TDP1/TDP2 Independently Suppress 5-Aza-2'-deoxycytidine-Induced Genomic Instability in Human TK6 Cell Line. Chem Res Toxicol 35:2059-2067.

  • N.L. Hindul, A. Jhita, D.G. Oprea, T.A. Hussain, O. Gonchar, M.A.M. Campillo, L. O'Regan, M.T. Kanemaki, A.M. Fry, K. Hirota, K. Tanaka, Construction of a human hTERT RPE-1 cell line with inducible Cre for editing of endogenous genes, Biol Open, 11 (2022).

  • K. Hirota, M. Ooka, N. Shimizu, K. Yamada, M. Tsuda, M.A. Ibrahim, S. Yamada, H. Sasanuma, M. Masutani, S. Takeda, XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA, Genes Cells, (2022).

  • 2021年

  • T. Abe, Y. Suzuki, T. Ikeya, K. Hirota, Targeting chromosome trisomy for chromosome editing, Sci Rep, 11 (2021) 18054.

  • A.A. Demin, K. Hirota, M. Tsuda, M. Adamowicz, R. Hailstone, J. Brazina, W. Gittens, I. Kalasova, Z. Shao, S. Zha, H. Sasanuma, H. Hanzlikova, S. Takeda, K.W. Caldecott, XRCC1 prevents toxic PARP1 trapping during DNA base excision repair, Mol Cell, 81 (2021) 3018-3030.e3015.

  • Senmatsu S, Asada R, Oda A, Hoffman CS, Ohta K, Hirota K. lncRNA transcription induces meiotic recombination through chromatin remodelling in fission yeast Commun Biol. 2021 Mar 5;4(1):295. doi: 10.1038/s42003-021-01798-8.

  • Y. Inomata, T. Abe, M. Tsuda, S. Takeda, K. Hirota, Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage, PLoS One, 16 (2021) e0252587.

  • R. Kawasumi, T. Abe, I. Psakhye, K. Miyata, K. Hirota, D. Branzei, Vertebrate CTF18 and DDX11 essential function in cohesion is bypassed by preventing WAPL-mediated cohesin release, Genes Dev, 35 (2021) 1368-1382.

  • W. Koda, S. Senmatsu, T. Abe, C.S. Hoffman, K. Hirota, Reciprocal stabilization of transcription factor binding integrates two signaling pathways to regulate fission yeast fbp1 transcription, Nucleic Acids Res, 49 (2021) 9809-9820.

  • A. Sassa, T. Fukuda, A. Ukai, M. Nakamura, R. Sato, S. Fujiwara, K. Hirota, S. Takeda, K.I. Sugiyama, M. Honma, M. Yasui, Follow-up genotoxicity assessment of Ames-positive/equivocal chemicals using the improved thymidine kinase gene mutation assay in DNA repair-deficient human TK6 cells, Mutagenesis, 36 (2021) 331-338.

  • Kojima K, Ooka M, Abe T, Hirota K. Pold4, the fourth subunit of replicative polymerase δ, suppresses gene conversion in the immunoglobulin-variable gene in avian DT40 cells DNA Repair (Amst). 2021 Apr;100:103056. doi: 10.1016/j.dnarep.2021.103056. Epub 2021 Feb 1.

  • 2020年

  • Shibata T, Iwasaki W, Hirota K. The intrinsic ability of double-stranded DNA to carry out D-loop and R-loop formation Comput Struct Biotechnol J. 2020 Nov 4;18:3350-3360. doi: 10.1016/j.csbj.2020.10.025. eCollection 2020.

  • Asada R, Senmatsu S, Montpetit B, Hirota K. Topoisomerase activity is linked to altered nucleosome positioning and transcriptional regulation in the fission yeast fbp1 gene. PLoS One. 2020 e0242348.

  • Senmatsu S, Hirota K. Roles of lncRNA transcription as a novel regulator of chromosomal function. Genes Genet Syst. 2020

  • Yamaki Y, Nobe Y, Koike M, Yamauchi Y, Hirota K, Takahashi N, Nakayama H, Isobe T, Taoka M. Direct Determination of Pseudouridine in RNA by Mass Spectrometry Coupled with Stable Isotope Labeling. Anal Chem. 2020 92(16):11349-11356.

  • Nakano T, Shoulkamy MI, Tsuda M, Sasanuma H, Hirota K, Takata M, Masunaga SI, Takeda S, Ide H, Bessho T, Tano K. Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells. PLoS One. 2020 15(6):e0234859.

  • Saha LK, Wakasugi M, Akter S, Prasad R, Wilson SH, Shimizu N, Sasanuma H, Huang SN, Agama K, Pommier Y, Matsunaga T, Hirota K, Iwai S, Nakazawa Y, Ogi T, Takeda S. Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells. Proc Natl Acad Sci U S A. 2020 117(25):14412-14420.

  • Akagawa R, Trinh HT, Saha LK, Tsuda M, Hirota K, Yamada S, Shibata A, Kanemaki MT, Nakada S, Takeda S, Sasanuma H. UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Break. i-Science 23. 101027 (2020)

  • 2019年

  • Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S. PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching. PLoS One 6;14(3)(2019)

  • Senmatsu S, Asada R, Abe T, Hoffman CS, Ohta K, Hirota K lncRNA transcriptional initiation induces chromatin remodeling within a limited range in the fission yeast fbp1 promoter. Sci Rep 9: 299 (2019)

  • 2018年

  • Abe T, Branzei D, Hirota K DNA Damage Tolerance Mechanisms Revealed from the Analysis of Immunoglobulin V Gene Diversification in Avian DT40 Cells. Genes (Basel) 9(2018)

  • Abe T, Kawasumi R, Giannattasio M, Dusi S, Yoshimoto Y, Miyata K, Umemura K, Hirota K, Branzei D AND-1 fork protection function prevents fork resection and is essential for proliferation. Nat Commun 9: 3091 (2018)

  • Abe T, Ooka M, Kawasumi R, Miyata K, Takata M, Hirota K, Branzei D Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites. Proc Natl Acad Sci U S A 115: 8412-8417 (2018)

  • Nakazato A, Kajita K, Ooka M, Akagawa R, Abe T, Takeda S, Branzei D, Hirota K SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells. DNA Repair (Amst) 68: 50-57 (2018)

  • Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S, Dertinger S Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms. Environ Mol Mutagen 59: 529-538 (2018)

  • Taoka M, Nobe Y, Yamaki Y, Sato K, Ishikawa H, Izumikawa K, Yamauchi Y, Hirota K, Nakayama H, Takahashi N, Isobe T Landscape of the complete RNA chemical modifications in the human 80S ribosome. Nucleic Acids Res 46: 9289-9298 (2018)

  • Umeda M, Tsunekawa C, Senmatsu S, Asada R, Abe T, Ohta K, Hoffman CS, Hirota K Histone Chaperone Asf1 Is Required for the Establishment of Repressive Chromatin in Schizosaccharomyces pombe fbp1 Gene Repression. Mol Cell Biol 38(2018)

  • Ooka M, Abe T, Cho K, Koike K, Takeda S, Hirota K Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression. PLoS One 13: e0192421(2018)

  • 2017年

  • Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K  The dominant role of proofreading exonuclease activity of replicative polymerase epsilon in cellular tolerance to cytarabine (Ara-C). Oncotarget 8: 33457-33474(2017)

  • Tsuda M, Cho K, Ooka M, Shimizu N, Watanabe R, Yasui A, Nakazawa Y, Ogi T, Harada H, Agama K, Nakamura J, Asada R, Fujiike H, Sakuma T, Yamamoto T, Murai J, Hiraoka M, Koike K, Pommier Y, Takeda S, Hirota K  ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair. PLoS One 12: e0188320(2017)

  • Kawasumi R, Abe T, Arakawa H, Garre M, Hirota K, Branzei D ESCO1/2's roles in chromosome structure and interphase chromatin organization. Genes Dev 31: 2136-2150(2017)

  • Fujisawa R, Ohashi E, Hirota K, Tsurimoto T Human CTF18-RFC clamp-loader complexed with non-synthesising DNA polymerase epsilon efficiently loads the PCNA sliding clamp. Nucleic Acids Res 45: 4550-4563(2017)

  • Asada R, Umeda M, Adachi A, Senmatsu S, Abe T, Iwasaki H, Ohta K, Hoffman CS, Hirota KRecruitment and delivery of the fission yeast Rst2 transcription factor via a local genome structure counteracts repression by Tup1-family corepressors. Nucleic Acids Res 45: 9361-9371 (2017)

  • Adachi A, Senmatsu S, Asada R, Abe T, Hoffman CS, Ohta K, Hirota K Interplay between chromatin modulators and histone acetylation regulates the formation of accessible chromatin in the upstream regulatory region of fission yeast fbp1. Genes Genet Syst (2017)

  • 2016年

  • Yamamoto J, Takahata C, Kuraoka I, Hirota K, Iwai S Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3'-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease. Molecules 21 (2016)

  • Takemata N, Oda A, Yamada T, Galipon J, Miyoshi T, Suzuki Y, Sugano S, Hoffman CS, Hirota K, Ohta K  Local potentiation of stress-responsive genes by upstream noncoding transcription. Nucleic Acids Res 44: 5174-89 (2016)

  • Ooka M, Takazawa H, Takeda S, Hirota K Cytotoxic and genotoxic profiles of benzopyrene and N-nitrosodimethylamine demonstrated using DNA repair deficient DT40 cells with metabolic activation. Chemosphere 144: 1901-7 (2016)

  • Ooka M, Kobayashi K, Abe T, Akiyama K, Hada M, Takeda S, Hirota K Determination of genotoxic potential by comparison of structurally related azo dyes using DNA repair-deficient DT40 mutant panels. Chemosphere 164: 106-112(2016)

  • Kobayashi K, Guilliam TA, Tsuda M, Yamamoto J, Bailey LJ, Iwai S, Takeda S, Doherty AJ, Hirota K  Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides. Cell Cycle 15: 1997-2008(2016)

  • Hirota K, Tsuda M, Mohiuddin, Tsurimoto T, Cohen IS, Livneh Z, Kobayashi K, Narita T, Nishihara K, Murai J, Iwai S, Guilbaud G, Sale JE, Takeda S In vivo evidence for translesion synthesis by the replicative DNA polymerase delta. Nucleic Acids Res 44: 7242-50(2016)

  • 2015年以前

  • Asada R, Takemata N, Hoffman CS, Ohta K, Hirota K  Antagonistic controls of chromatin and mRNA start site selection by Tup family corepressors and the CCAAT-binding factor. Mol Cell Biol 35: 847-55(2015)

  • Hirota K, Yoshikiyo K, Guilbaud G, Tsurimoto T, Murai J, Tsuda M, Phillips LG, Narita T, Nishihara K, Kobayashi K, Yamada K, Nakamura J, Pommier Y, Lehmann A, Sale JE, Takeda S The POLD3 subunit of DNA polymerase delta can promote translesion synthesis independently of DNA polymerase zeta. Nucleic Acids Res 43: 1671-83(2015)

  • Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma HRelative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines. Genes Cells 20: 1059-76 (2015)

  • Kobayashi K, Fujii T, Asada R, Ooka M, Hirota K  Development of a targeted flip-in system in avian DT40 cells. PLoS One 10: e0122006(2015)

  • Kobayashi S, Kasaishi Y, Nakada S, Takagi T, Era S, Motegi A, Chiu RK, Takeda S, Hirota K  Rad18 and Rnf8 facilitate homologous recombination by two distinct mechanisms, promoting Rad51 focus formation and suppressing the toxic effect of nonhomologous end joining. Oncogene 34: 4403-11(2015)

  • Shimizu N, Ooka M, Takagi T, Takeda S, Hirota K  Distinct DNA Damage Spectra Induced by Ionizing Radiation in Normoxic and Hypoxic Cells. Radiat Res 184: 442-8(2015)

  • Tada K, Kobayashi M, Takiuchi Y, Iwai F, Sakamoto T, Nagata K, Shinohara M, Io K, Shirakawa K, Hishizawa M, Shindo K, Kadowaki N, Hirota K, Yamamoto J, Iwai S, Sasanuma H, Takeda S, Takaori-Kondo A Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia. Sci Adv 1: e1400203(2015)

  • Yamamoto KN, Hirota K, Takeda S, Haeno H Evolution of pre-existing versus acquired resistance to platinum drugs and PARP inhibitors in BRCA-associated cancers. PLoS One 9: e105724 (2014)

  • Taoka M, Ishikawa D, Nobe Y, Ishikawa H, Yamauchi Y, Terukina G, Nakayama H, Hirota K, Takahashi N, Isobe T RNA cytidine acetyltransferase of small-subunit ribosomal RNA: identification of acetylation sites and the responsible acetyltransferase in fission yeast, Schizosaccharomyces pombe. PLoS One 9: e112156 (2014)

  • Saito Y, Takeda J, Adachi K, Nobe Y, Kobayashi J, Hirota K, Oliveira DV, Taoka M, Isobe T RNase MRP cleaves pre-tRNASer-Met in the tRNA maturation pathway. PLoS One 9: e112488 (2014)

  • Mohiuddin, Keka IS, Evans TJ, Hirota K, Shimizu H, Kono K, Takeda S, Hirano S A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes. Arch Toxicol 88: 145-60 (2014)

  • Hirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss. Genes Cells 19: 743-54 (2014)

  • Al Abo M, Dejsuphong D, Hirota K, Yonetani Y, Yamazoe M, Kurumizaka H, Takeda S Compensatory functions and interdependency of the DNA-binding domain of BRCA2 with the BRCA1-PALB2-BRCA2 complex. Cancer Res 74: 797-807(2014)

  • Saito Y, Takeda J, Okada M, Kobayashi J, Kato A, Hirota K, Taoka M, Matsumoto T, Komatsu K, Isobe T The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination. Sci Rep 3: 2022 (2013)

  • Kikuchi K, Narita T, Pham VT, Iijima J, Hirota K, Keka IS, Mohiuddin, Okawa K, Hori T, Fukagawa T, Essers J, Kanaar R, Whitby MC, Sugasawa K, Taniguchi Y, Kitagawa K, Takeda S Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination. Cancer Res 73: 4362-71 (2013)

  • Fujita M, Sasanuma H, Yamamoto KN, Harada H, Kurosawa A, Adachi N, Omura M, Hiraoka M, Takeda S, Hirota K Interference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaks. PLoS One 8: e60043 (2013)

  • Miyoshi T, Ito M, Kugou K, Yamada S, Furuichi M, Oda A, Yamada T, Hirota K, Masai H, Ohta K A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint. Mol Cell 47: 722-33 (2012)

  • Yamamoto KN, Kobayashi S, Tsuda M, Kurumizaka H, Takata M, Kono K, Jiricny J, Takeda S, Hirota K Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway. Proc Natl Acad Sci U S A 108: 6492-6 (2011)

  • Yamamoto KN, Hirota K, Kono K, Takeda S, Sakamuru S, Xia M, Huang R, Austin CP, Witt KL, Tice RR Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines. Environ Mol Mutagen 52: 547-61 (2011)

  • Takaku M, Tsujita T, Horikoshi N, Takizawa Y, Qing Y, Hirota K, Ikura M, Ikura T, Takeda S, Kurumizaka HPurification of the human SMN-GEMIN2 complex and assessment of its stimulation of RAD51-mediated DNA recombination reactions. Biochemistry 50: 6797-805 (2011)

  • Y, Yamazoe M, Hirota K, Dejsuphong D, Sakai W, Yamamoto KN, Bishop DK, Wu X, Takeda S The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PLoS Genet 7: e1002148 (2011)

  • Murai J, Yang K, Dejsuphong D, Hirota K, Takeda S, D'Andrea AD The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol 31: 2462-9 (2011)

  • Yoshikiyo K, Kratz K, Hirota K, Nishihara K, Takata M, Kurumizaka H, Horimoto S, Takeda S, Jiricny J KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents. Proc Natl Acad Sci U S A 107: 21553-7 (2010)

  • Takizawa Y, Qing Y, Takaku M, Ishida T, Morozumi Y, Tsujita T, Kogame T, Hirota K, Takahashi M, Shibata T, Kurumizaka H, Takeda S GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination. Nucleic Acids Res 38: 5059-74 (2010)

  • Nemoto N, Udagawa T, Ohira T, Jiang L, Hirota K, Wilkinson CR, Bahler J, Jones N, Ohta K, Wek RC, Asano K The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation. J Mol Biol 404: 183-201 (2010)

  • Narita T, Tsurimoto T, Yamamoto J, Nishihara K, Ogawa K, Ohashi E, Evans T, Iwai S, Takeda S, Hirota K Human replicative DNA polymerase delta can bypass T-T (6-4) ultraviolet photoproducts on template strands. Genes Cells 15: 1228-39 (2010)

  • Kohzaki M, Nishihara K, Hirota K, Sonoda E, Yoshimura M, Ekino S, Butler JE, Watanabe M, Halazonetis TD, Takeda S DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken. J Cell Biol 189: 1117-27 (2010)

  • Hirota K, Sonoda E, Kawamoto T, Motegi A, Masutani C, Hanaoka F, Szuts D, Iwai S, Sale JE, Lehmann A, Takeda S Simultaneous disruption of two DNA polymerases, Poleta and Polzeta, in Avian DT40 cells unmasks the role of Poleta in cellular response to various DNA lesions. PLoS Genet 6 (2010)

  • Evans TJ, Yamamoto KN, Hirota K, Takeda S Mutant cells defective in DNA repair pathways provide a sensitive high-throughput assay for genotoxicity. DNA Repair (Amst) 9: 1292-8 (2010)

  • Hirota K, Fukuda T, Yamada T, Ohta K Analysis of chromatin structure at meiotic DSB sites in yeasts. Methods Mol Biol 557: 253-66 (2009)

  • Hirota K, Ohta K Transcription of mRNA-type long non-coding RNAs (mlonRNAs) disrupts chromatin array. Commun Integr Biol 2: 25-6 (2009)

  • Hirota K, Ohta K Cascade transcription of mRNA-type long non-coding RNAs (mlonRNAs) and local chromatin remodeling. Epigenetics 4: 5-7 (2009)

  • Kikuchi K, Abdel-Aziz HI, Taniguchi Y, Yamazoe M, Takeda S, Hirota K Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences. J Biol Chem 284: 26360-7 (2009)

  • Yamada K, Hirota K, Mizuno K, Shibata T, Ohta K Essential roles of Snf21, a Swi2/Snf2 family chromatin remodeler, in fission yeast mitosis. Genes Genet Syst 83: 361-72 (2008)

  • Sasanuma H, Hirota K, Fukuda T, Kakusho N, Kugou K, Kawasaki Y, Shibata T, Masai H, Ohta K Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination. Genes Dev 22: 398-410 (2008)

  • Hirota K, Mizuno K, Shibata T, Ohta K Distinct chromatin modulators regulate the formation of accessible and repressive chromatin at the fission yeast recombination hotspot ade6-M26. Mol Biol Cell 19: 1162-73 (2008)

  • Hirota K, Miyoshi T, Kugou K, Hoffman CS, Shibata T, Ohta K Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs. Nature 456: 130-4 (2008)

  • Hikiba J, Hirota K, Kagawa W, Ikawa S, Kinebuchi T, Sakane I, Takizawa Y, Yokoyama S, Mandon-Pepin B, Nicolas A, Shibata T, Ohta K, Kurumizaka H Structural and functional analyses of the DMC1-M200V polymorphism found in the human population. Nucleic Acids Res 36: 4181-90 (2008)

  • In-cell Viscosity Measurement Using a Fluorescence Up-conversion Microscope. . T. Fujino, K. Hirota, K. Ohta and T. Tahara, Chemistry Letters 37, 1240 (2008). (IF=1.485)

  • Hirota K, Steiner WW, Shibata T, Ohta K Multiple modes of chromatin configuration at natural meiotic recombination hot spots in fission yeast. Eukaryot Cell 6: 2072-80 (2007)

  • Ogino K, Hirota K, Matsumoto S, Takeda T, Ohta K, Arai K, Masai H Hsk1 kinase is required for induction of meiotic dsDNA breaks without involving checkpoint kinases in fission yeast. Proc Natl Acad Sci U S A 103: 8131-6 (2006) (IF=9.58)

  • Hirota K, Hoffman CS, Ohta K Reciprocal nuclear shuttling of two antagonizing Zn finger proteins modulates Tup family corepressor function to repress chromatin remodeling. Eukaryot Cell 5: 1980-9 (2006)

  • Yamada T, Mizuno K, Hirota K, Kon N, Wahls WP, Hartsuiker E, Murofushi H, Shibata T, Ohta K Roles of histone acetylation and chromatin remodeling factor in a meiotic recombination hotspot. EMBO J 23: 1792-803 (2004)

  • Hirota K, Hasemi T, Yamada T, Mizuno KI, Hoffman CS, Shibata T, Ohta K Fission yeast global repressors regulate the specificity of chromatin alteration in response to distinct environmental stresses. Nucleic Acids Res 32: 855-62 (2004)

  • Davidson MK, Shandilya HK, Hirota K, Ohta K, Wahls WP Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2+. J Biol Chem 279: 50857-63 (2004)

  • Hirota K, Tanaka K, Ohta K, Yamamoto M Gef1p and Scd1p, the Two GDP-GTP exchange factors for Cdc42p, form a ring structure that shrinks during cytokinesis in Schizosaccharomyces pombe. Mol Biol Cell 14: 3617-27 (2003)

  • Hirota K, Hoffman CS, Shibata T, Ohta K Fission yeast Tup1-like repressors repress chromatin remodeling at the fbp1+ promoter and the ade6-M26 recombination hotspot. Genetics 165: 505-15 (2003)

  • Hirota K, Tanaka K, Watanabe Y, Yamamoto M Functional analysis of the C-terminal cytoplasmic region of the M-factor receptor in fission yeast. Genes Cells 6: 201-14 (2001)

  •  

  • ​

  • 遺伝的に改変された細胞を製造する方法発明者：武田　俊一, 廣田　耕志　特願2009-138902

  • 耐熱性多頻度ＤＮＡ切断酵素の細胞内活性化によるゲノム再編成の誘発方法

  • 廣田耕志、太田邦史、柴田武彦、瀬尾秀宗　国内特許　特願2004-338029国際特許PCT-JP2005-21423

  •  

  • 日本語総説

  • 酵母SRG１, mlonRNAによる遺伝子発現制御　実験医学増刊ノンコーディングRNAテキストブック　2018年　浅田隆大、廣田耕志　

  • シスプラチン耐性の分子機構　血液内科　65(4) 498-503 2012年　笹沼博之　廣田耕志　武田俊一

  • シスプラチンの効果を妨害するメカニズムの解明 月刊化学2011年6月号  廣田耕志

  • シスプラチン耐性の分子機構　医学の歩み241巻10号  2011 廣田耕志　武田俊一

  • 基礎の基礎　細胞工学2010年１月号　廣田耕志、武田俊一

  • mlonRNA仮説 ノンコーディングRNA転写による新規クロマチン構造変化機構

  • 化学と生物 2009 5月号　廣田耕志、太田邦史

  • クロマチン再編成をつうじて遺伝子活性化にかかわるmRNA型長鎖ノンコーディングRNA

  • 蛋白質核酸酵素2009 5月号 廣田耕志、太田邦史

  • 減数分裂期の組換え開始制御」染色体サイクルの分子メカニズム５章−４（羊土社）2007　廣田耕志、福田智行、太田邦史

  • 体細胞DNA複製に重要な役割を果たす分裂酵母Cdc7類似キナーゼ，Hsk1タンパク質は減数分裂期組換えの開始に必要とされる　細胞工学 2006 9号 荻野桂子，廣田耕志，太田邦史，正井久雄

  •  

  • 書籍

  • 化学結合論—分子の構造と機能　（NHK出版）2017年　分担執筆

  • ​

bottom of page